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APOE2 VARIANT

MedGen UID:
864317
•Concept ID:
C4015880
•
Finding
OMIM®: 107741

Professional guidelines

PubMed

Contribution of the APOE Genotype to Cognitive Impairment in Individuals With NOTCH3 Cysteine-Altering Variants.
Cheng YW, Liao YC, Chen CH, Chung CP, Fann CSJ, Chang CC, Lee YC, Tang SC
J Am Heart Assoc 2023 Nov 21;12(22):e032689. Epub 2023 Nov 20 doi: 10.1161/JAHA.123.032689. PMID: 37982214Free PMC Article
Diagnosis of Familial Dysbetalipoproteinemia Based on the Lipid Abnormalities Driven by APOE2/E2 Genotype.
Bea AM, Cenarro A, Marco-Bened V, Laclaustra M, Martn C, Ibarretxe D, Pint X, Arrobas T, Vials C, Civeira F, Olmos S
Clin Chem 2023 Feb 1;69(2):140-148. doi: 10.1093/clinchem/hvac213. PMID: 36644927
APOE e4-genotype and lifestyle interaction on cognitive performance: Results of the LIFE-Adult-study.
Rodriguez FS, Schroeter ML, Arélin K, Witte AV, Baber R, Burkhardt R, Engel C, Löffler M, Thiery J, Villringer A, Luck T, Riedel-Heller SG
Health Psychol 2018 Feb;37(2):194-205. Epub 2017 Dec 7 doi: 10.1037/hea0000515. PMID: 29215900

Recent clinical studies

Etiology

APOE2 mitigates disease-related phenotypes in an isogenic hiPSC-based model of Alzheimer's disease.
Brookhouser N, Raman S, Frisch C, Srinivasan G, Brafman DA
Mol Psychiatry 2021 Oct;26(10):5715-5732. Epub 2021 Apr 9 doi: 10.1038/s41380-021-01076-3. PMID: 33837271Free PMC Article
AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease.
Rosenberg JB, Kaplitt MG, De BP, Chen A, Flagiello T, Salami C, Pey E, Zhao L, Ricart Arbona RJ, Monette S, Dyke JP, Ballon DJ, Kaminsky SM, Sondhi D, Petsko GA, Paul SM, Crystal RG
Hum Gene Ther Clin Dev 2018 Mar;29(1):24-47. Epub 2018 Mar 13 doi: 10.1089/humc.2017.231. PMID: 29409358Free PMC Article

Therapy

AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease.
Rosenberg JB, Kaplitt MG, De BP, Chen A, Flagiello T, Salami C, Pey E, Zhao L, Ricart Arbona RJ, Monette S, Dyke JP, Ballon DJ, Kaminsky SM, Sondhi D, Petsko GA, Paul SM, Crystal RG
Hum Gene Ther Clin Dev 2018 Mar;29(1):24-47. Epub 2018 Mar 13 doi: 10.1089/humc.2017.231. PMID: 29409358Free PMC Article

Prognosis

Apolipoprotein E2 Stimulates Protein Synthesis and Promotes Melanoma Progression and Metastasis.
Adaku N, Ostendorf BN, Mei W, Tavazoie SF
Cancer Res 2023 Sep 15;83(18):3013-3025. doi: 10.1158/0008-5472.CAN-23-1252. PMID: 37335131Free PMC Article

Clinical prediction guides

Apolipoprotein E2 Stimulates Protein Synthesis and Promotes Melanoma Progression and Metastasis.
Adaku N, Ostendorf BN, Mei W, Tavazoie SF
Cancer Res 2023 Sep 15;83(18):3013-3025. doi: 10.1158/0008-5472.CAN-23-1252. PMID: 37335131Free PMC Article
Genetic and Mechanistic Insights into the Modulation of Circulating Lipoprotein (a) Concentration by Apolipoprotein E Isoforms.
Chemello K, Blom DJ, Marais AD, Lambert G, Blanchard V
Curr Atheroscler Rep 2022 Jun;24(6):399-405. Epub 2022 Mar 30 doi: 10.1007/s11883-022-01016-8. PMID: 35355214

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